SENP1 Antikörper (AA 262-289)

Produktnummer ABIN1881788

Produktdetails anti-SENP1 Antikörper

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Bindungsspezifität: AA 262-289

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.

Klon: RB40856

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SENP1 Antikörper (ABIN1881788)

Bawa-Khalfe, Cheng, Lin, Ittmann, Yeh: "SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25859-66, (2010) (PubMed).

Yu, Ji, Zhang, Renda, He, Lin, Cheng, Chen, Krause, Min: "SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1183-95, (2010) (PubMed).

Sharma, Murillas, Zhang, Kuehn: "N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies." in: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1227-34, (2010) (PubMed).

Li, Luo, Yu, Lin, Luo, Zhang, He, Kim, Kim, Tang, Min: "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis." in: Cell death and differentiation, Vol. 15, Issue 4, pp. 739-50, (2008) (PubMed).

Cheng, Kang, Zhang, Yeh: "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia." in: Cell, Vol. 131, Issue 3, pp. 584-95, (2007) (PubMed).

Details zu SENP1

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Andere Bezeichnung: Senp1 (SENP1 Produkte)

Hintergrund: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.

Molekulargewicht: 72511

NCBI Accession: NP_659100

UniProt: P59110

Pathways: Positive Regulation of Endopeptidase Activity