RLIM Antikörper (AA 199-227)

Produktnummer ABIN1881751

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RLIM in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für RLIM Antikörper (AA 199-227) (ABIN1881751)

Target: RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RLIM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42228

Produktdetails anti-RLIM Antikörper

Bindungsspezifität: AA 199-227

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RLIM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the Central region of human RLIM.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RLIM Antikörper (ABIN1881751)

Jonkers, Barakat, Achame, Monkhorst, Kenter, Rentmeester, Grosveld, Grootegoed, Gribnau: "RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation." in: Cell, Vol. 139, Issue 5, pp. 999-1011, (2009) (PubMed).

Her, Chung: "Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1." in: The Journal of biological chemistry, Vol. 284, Issue 13, pp. 8557-66, (2009) (PubMed).

Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, (2007) (PubMed).

Hiratani, Yamamoto, Mochizuki, Ohmori, Taira: "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions." in: Development (Cambridge, England), Vol. 130, Issue 17, pp. 4161-75, (2003) (PubMed).

Ostendorff, Peirano, Peters, Schlüter, Bossenz, Scheffner, Bach: "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors." in: Nature, Vol. 416, Issue 6876, pp. 99-103, (2002) (PubMed).

Details zu RLIM

Target: RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))

Andere Bezeichnung: RLIM

Hintergrund: The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Molekulargewicht: 68549

NCBI Accession: NP_057204, NP_899196

UniProt: Q9NVW2