Netrin 1 Antikörper (C-Term)

Produktnummer ABIN1881590

Der Kaninchen Polyklonal Anti-Netrin 1-Antikörper wurde für WB validiert. Er ist geeignet, Netrin 1 in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für Netrin 1 Antikörper (C-Term) (ABIN1881590)

Target: Netrin 1 (NTN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Netrin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB44404

Produktdetails anti-Netrin 1 Antikörper

Bindungsspezifität: AA 568-596, C-Term

Homologie: C, M, Pig

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 568-596 amino acids from the C-terminal region of human NTN1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Netrin 1 Antikörper (ABIN1881590)

Li, Liu, Wang, Liu, Liu, Li, Wan, Wang, Zhang, Jin, Liu, Zhu, Liu: "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 11, pp. 2517-28, (2010) (PubMed).

Liu, Li, Wang, Kar, Guan, Rao, Wu: "DSCAM functions as a netrin receptor in commissural axon pathfinding." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 8, pp. 2951-6, (2009) (PubMed).

Mazelin, Bernet, Bonod-Bidaud, Pays, Arnaud, Gespach, Bredesen, Scoazec, Mehlen: "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis." in: Nature, Vol. 431, Issue 7004, pp. 80-4, (2004) (PubMed).

Meyerhardt, Caca, Eckstrand, Hu, Lengauer, Banavali, Look, Fearon: "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 1, pp. 35-42, (1999) (PubMed).

Details zu Netrin 1

Target: Netrin 1 (NTN1)

Andere Bezeichnung: NTN1

Hintergrund: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Molekulargewicht: 67748

NCBI Accession: NP_004813

UniProt: O95631

Pathways: Regulation of Cell Size