Neurogenin 1 Antikörper (AA 112-138)

Produktnummer ABIN1881577

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Neurogenin 1 in WB. Er zeigt eine Reaktivität gegenüber Zebrafisch (Danio rerio) und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für Neurogenin 1 Antikörper (AA 112-138) (ABIN1881577)

Target: Neurogenin 1 (NEUROG1)

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurogenin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Neurogenin 1 Antikörper

Bindungsspezifität: AA 112-138

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DANRE neurog1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-138 amino acids from the Central region of DANRE neurog1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Neurogenin 1 Antikörper (ABIN1881577)

Korzh, Sleptsova, Liao, He, Gong: "Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 213, Issue 1, pp. 92-104, (1999) (PubMed).

Kim, Bae, Yamanaka, Yamashita, Shimizu, Fujii, Park, Yeo, Huh, Hibi, Hirano: "Overexpression of neurogenin induces ectopic expression of HuC in zebrafish." in: Neuroscience letters, Vol. 239, Issue 2-3, pp. 113-6, (1998) (PubMed).

Blader, Fischer, Gradwohl, Guillemot, Strähle: "The activity of neurogenin1 is controlled by local cues in the zebrafish embryo." in: Development (Cambridge, England), Vol. 124, Issue 22, pp. 4557-69, (1998) (PubMed).

Details zu Neurogenin 1

Target: Neurogenin 1 (NEUROG1)

Andere Bezeichnung: neurog1

Hintergrund: Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons, involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.

Molekulargewicht: 22911

NCBI Accession: NP_571116

UniProt: O42606