MTAP Antikörper (N-Term)

Produktnummer ABIN1881557

Der Kaninchen Polyklonal Anti-MTAP-Antikörper wurde für WB validiert. Er ist geeignet, MTAP in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für MTAP Antikörper (N-Term) (ABIN1881557)

Target: MTAP (Methylthioadenosine phosphorylase (MTAP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42759

Produktdetails anti-MTAP Antikörper

Bindungsspezifität: AA 8-37, N-Term

Homologie: B, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human MTAP.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-MTAP Antikörper (ABIN1881557)

Newton-Bishop, Chang, Iles, Taylor, Bakker, Chan, Leake, Karpavicius, Haynes, Fitzgibbon, Elliott, Kanetsky, Harland, Barrett, Bishop: "Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 8, pp. 2043-54, (2010) (PubMed).

Zhang, Cheng, Yan, Chen, Wang, Yang: "[Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity]." in: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, Vol. 31, Issue 1, pp. 83-6, (2010) (PubMed).

Huang, Li, Yu, Chou, Tzeng, Hu, Uen, Tian, Wang, Fang, Huang, Wei, Wu, Li: "Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 22, pp. 6963-72, (2009) (PubMed).

Details zu MTAP

Target: MTAP (Methylthioadenosine phosphorylase (MTAP))

Andere Bezeichnung: MTAP

Hintergrund: This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Molekulargewicht: 31236

NCBI Accession: NP_002442

UniProt: Q13126

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process