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LIN7B Antikörper (N-Term)

Der Rabbit Polyclonal Anti-LIN7B-Antikörper wurde für WB validiert. Er ist geeignet, LIN7B in Proben von Human, Mouse zu detektieren. Es sind 4+ Publikationen verfügbar.
Produktnummer ABIN1881500

Kurzübersicht für LIN7B Antikörper (N-Term) (ABIN1881500)

Target

Alle LIN7B Antikörper anzeigen
LIN7B (Lin-7 Homolog B (LIN7B))

Reaktivität

  • 13
  • 9
  • 2
Human, Maus

Wirt

  • 11
  • 2
  • 1
Kaninchen

Klonalität

  • 12
  • 2
Polyklonal

Konjugat

  • 9
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIN7B Antikörper ist unkonjugiert

Applikation

  • 14
  • 10
  • 2
  • 2
  • 1
Western Blotting (WB)

Klon

RB40557
  • Bindungsspezifität

    AA 35-62, N-Term

    Homologie

    B, Rat

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Zucker, Kama, Kuhn, Thu, Orlando, Dunah, Gokce, Taylor, Lambeck, Friedrich, Lindenberg, Faull, Weiller, Young, Luthi-Carter: "Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 9, pp. 880-95, (2010) (PubMed).

    Sudo, Ito, Iwamoto, Morishita, Asano, Nagata: "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons." in: Neuroscience research, Vol. 56, Issue 4, pp. 347-55, (2006) (PubMed).

    Li, Benard, Margolskee: "Ggamma13 interacts with PDZ domain-containing proteins." in: The Journal of biological chemistry, Vol. 281, Issue 16, pp. 11066-73, (2006) (PubMed).

    Kawai, Fukuda, Mukai, Murata: "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39200-7, (2005) (PubMed).

  • Target

    LIN7B (Lin-7 Homolog B (LIN7B))

    Andere Bezeichnung

    LIN7B

    Hintergrund

    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

    Molekulargewicht

    22896

    NCBI Accession

    NP_071448

    UniProt

    Q9HAP6

    Pathways

    Synaptic Membrane
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