Keratin 86 Antikörper (AA 300-327)

Produktnummer ABIN1881488

Produktdetails anti-Keratin 86 Antikörper

Target: Keratin 86 (KRT86)

Bindungsspezifität: AA 300-327

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Keratin 86 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Sh, B, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86.

Klon: RB42669

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Keratin 86 Antikörper (ABIN1881488)

ZHANG, MENG, ZHAO, TIAN: "Mutation E402K of the hHb6 in a Chinese Han family with monilethrix." in: European journal of dermatology : EJD, Vol. 19, Issue 5, pp. 508-9, (2009) (PubMed).

Feng, Liu, Yang: "[Analysis of human hair basic keratin 6 gene mutation in a Chinese Han family with monilethrix]." in: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Vol. 25, Issue 2, pp. 141-4, (2008) (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, (2007) (PubMed).

Schweizer, Bowden, Coulombe, Langbein, Lane, Magin, Maltais, Omary, Parry, Rogers, Wright: "New consensus nomenclature for mammalian keratins." in: The Journal of cell biology, Vol. 174, Issue 2, pp. 169-74, (2006) (PubMed).

Details zu Keratin 86

Target: Keratin 86 (KRT86)

Andere Bezeichnung: KRT86 (KRT86 Produkte)

Synonyme: Kb26 antikoerper, KRT86 antikoerper, HB6 antikoerper, Hb1 antikoerper, KRTHB1 antikoerper, KRTHB6 antikoerper, MNX antikoerper, hHb6 antikoerper, 5430421N21Rik antikoerper, AI325212 antikoerper, Khb4 antikoerper, Krt2-10 antikoerper, Krt2-11 antikoerper, MHb4 antikoerper, keratin 86 antikoerper, hair keratin type II intermediate filament antikoerper, Krt86 antikoerper, KRT86 antikoerper, KRT2.11 antikoerper

Hintergrund: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle, this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.

Molekulargewicht: 53501

NCBI Accession: NP_002275

UniProt: O43790