PDX1 Antikörper (AA 43-72)

Produktnummer ABIN1881463

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDX1 in WB. Es zeigt Reaktivität gegenüber Proben von Human.Es wurde in 1 Publikation zitiert.

Kurzübersicht für PDX1 Antikörper (AA 43-72) (ABIN1881463)

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB16670

Produktdetails anti-PDX1 Antikörper

Bindungsspezifität: AA 43-72

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from human IPF.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PDX1 Antikörper (ABIN1881463)

Ma, Chen, Wang, Xia, Zhu, Liang, Gu, Qiao, Dai, Zou, Li, Zhang, Lan, Wong: "Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1327-33, (2008) (PubMed).

Details zu PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Andere Bezeichnung: IPF

Hintergrund: IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Molekulargewicht: 30771

NCBI Accession: NP_000200

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location