HIST1H2BJ,HIST1H2BK,HIST3H2BB (AA 98-126), (C-Term) Antikörper

Produktnummer ABIN1881414

Produktdetails

Target: HIST1H2BJ,HIST1H2BK,HIST3H2BB

Bindungsspezifität: AA 98-126, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Homologie: X, B, Pr, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HIST1H2BJ/HIST1H2BK/HIST3H2BB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the C-terminal region of human HIST1H2BJ/HIST1H2BK/HIST3H2BB.

Klon: RB40819

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen

Shi, Levinson, Duan, Sanders, Zheng, Peer, Dudbridge, Holmans, Whittemore, Mowry, Olincy, Amin, Cloninger, Silverman, Buccola, Byerley, Black, Crowe, Oksenberg, Mirel, Kendler, Freedman, Gejman: "Common variants on chromosome 6p22.1 are associated with schizophrenia." in: Nature, Vol. 460, Issue 7256, pp. 753-7, (2009) (PubMed).

Benyamin, McRae, Zhu, Gordon, Henders, Palotie, Peltonen, Martin, Montgomery, Whitfield, Visscher: "Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels." in: American journal of human genetics, Vol. 84, Issue 1, pp. 60-5, (2009) (PubMed).

Beck, Nielsen, Matthiesen, Jensen, Sehested, Finn, Grauslund, Hansen, Jensen: "Quantitative proteomic analysis of post-translational modifications of human histones." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 7, pp. 1314-25, (2006) (PubMed).

Pavri, Zhu, Li, Trojer, Mandal, Shilatifard, Reinberg: "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II." in: Cell, Vol. 125, Issue 4, pp. 703-17, (2006) (PubMed).

Antigendetails

Target: HIST1H2BJ,HIST1H2BK,HIST3H2BB

Hintergrund: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq].

Molekulargewicht: 13904

NCBI Accession: NP_066402

UniProt: P06899