Granulin Antikörper (C-Term)

Produktnummer ABIN1881391

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Granulin in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für Granulin Antikörper (C-Term) (ABIN1881391)

Target: Granulin (GRN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Granulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB44397

Produktdetails anti-Granulin Antikörper

Bindungsspezifität: AA 563-591, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-591 amino acids from the C-terminal region of human GRN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Granulin Antikörper (ABIN1881391)

Bhandari, Bateman: "Structure and chromosomal location of the human granulin gene." in: Biochemical and biophysical research communications, Vol. 188, Issue 1, pp. 57-63, (1992) (PubMed).

Plowman, Green, Neubauer, Buckley, McDonald, Todaro, Shoyab: "The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth." in: The Journal of biological chemistry, Vol. 267, Issue 18, pp. 13073-8, (1992) (PubMed).

Bhandari, Palfree, Bateman: "Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 5, pp. 1715-9, (1992) (PubMed).

Details zu Granulin

Target: Granulin (GRN)

Andere Bezeichnung: GRN

Hintergrund: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Molekulargewicht: 63544

NCBI Accession: NP_002078

UniProt: P28799