GAR1 Antikörper (AA 86-114)

Produktnummer ABIN1881363

Dieses Anti-GAR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GAR1 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für GAR1 Antikörper (AA 86-114) (ABIN1881363)

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB39831

Produktdetails anti-GAR1 Antikörper

Bindungsspezifität: AA 86-114

Homologie: Zf, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human GAR1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GAR1 Antikörper (ABIN1881363)

Hamma, Ferré-DAmaré: "The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 805-9, (2010) (PubMed).

Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, (2010) (PubMed).

Pigullo, Pavesi, Dianzani, Santamaria, Svahn, Risso, Van Lint, Pillon, Iori, Longoni, Ramenghi, Lanciotti, Dufour: "NOLA1 gene mutations in acquired aplastic anemia." in: Pediatric blood & cancer, Vol. 52, Issue 3, pp. 376-8, (2009) (PubMed).

Details zu GAR1

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Andere Bezeichnung: GAR1

Hintergrund: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.

Molekulargewicht: 22348

NCBI Accession: NP_061856, NP_127460

UniProt: Q9NY12