FBXW5 Antikörper (AA 324-350)

Produktnummer ABIN1881341

This anti-FBXW5 antibody (ABIN1881341) is a Rabbit Polyclonal antibody detecting FBXW5 in WB. Suitable for Human.

Kurzübersicht für FBXW5 Antikörper (AA 324-350) (ABIN1881341)

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40653

Produktdetails anti-FBXW5 Antikörper

Bindungsspezifität: AA 324-350

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FBXW5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-350 amino acids from the Central region of human FBXW5.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-FBXW5 Antikörper (ABIN1881341)

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Minoda, Sakurai, Kobayashi, Yoshimura, Takaesu: "An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway." in: Biochemical and biophysical research communications, Vol. 381, Issue 3, pp. 412-7, (2009) (PubMed).

Hu, Zacharek, He, Lee, Shumway, Duronio, Xiong: "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase." in: Genes & development, Vol. 22, Issue 7, pp. 866-71, (2008) (PubMed).

Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).

Details zu FBXW5

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Andere Bezeichnung: FBXW5

Hintergrund: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Molekulargewicht: 63922

NCBI Accession: NP_061871

UniProt: Q969U6