Estrogen Receptor alpha Antikörper (C-Term)

Produktnummer ABIN1881319

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Estrogen Receptor alpha in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für Estrogen Receptor alpha Antikörper (C-Term) (ABIN1881319)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41114

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: AA 283-312, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ESR1 isoform4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-312 amino acids from the C-terminal region of human ESR1 isoform4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Estrogen Receptor alpha Antikörper (ABIN1881319)

Zhang, Ren, Wei, Chong, Yang, He, Chen, Lai: "Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma." in: BMC cancer, Vol. 16, Issue 1, pp. 926, (2017) (PubMed).

Geradts, Bean, Bentley, Barry: "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." in: Cancer investigation, Vol. 28, Issue 9, pp. 969-77, (2010) (PubMed).

Hayes, Skaar, Rae, Henry, Nguyen, Stearns, Li, Philips, Desta, Flockhart: "Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results." in: Clinical pharmacology and therapeutics, Vol. 88, Issue 5, pp. 626-9, (2010) (PubMed).

Lupien, Meyer, Bailey, Eeckhoute, Cook, Westerling, Zhang, Carroll, Rhodes, Liu, Brown: "Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance." in: Genes & development, Vol. 24, Issue 19, pp. 2219-27, (2010) (PubMed).

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: ESR1

Hintergrund: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Molekulargewicht: 36.5K

NCBI Accession: NP_000116, NP_001116212, NP_001116213, NP_001116214

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly