EPC1 Antikörper (AA 305-334)

Produktnummer ABIN1881300

Dieses Anti-EPC1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EPC1 in WB. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für EPC1 Antikörper (AA 305-334) (ABIN1881300)

Target: EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EPC1 Antikörper

Bindungsspezifität: AA 305-334

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the Central region of human EPC1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-EPC1 Antikörper (ABIN1881300)

Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, (2004) (PubMed).

Shimono, Murakami, Hasegawa, Takahashi: "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39411-9, (2001) (PubMed).

Details zu EPC1

Target: EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))

Andere Bezeichnung: EPC1

Hintergrund: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Molekulargewicht: 93463

NCBI Accession: NP_001258933, NP_001258948, NP_001269320, NP_079485

UniProt: Q9H2F5

Pathways: Regulation of Muscle Cell Differentiation