EBP Antikörper (C-Term)

Produktnummer ABIN1881278

Der Kaninchen Polyklonal Anti-EBP-Antikörper wurde für WB validiert. Er ist geeignet, EBP in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für EBP Antikörper (C-Term) (ABIN1881278)

Target: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41564

Produktdetails anti-EBP Antikörper

Bindungsspezifität: AA 201-230, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the C-terminal region of human EBP.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-EBP Antikörper (ABIN1881278)

Ausavarat, Tanpaiboon, Tongkobpetch, Suphapeetiporn, Shotelersuk: "Two novel EBP mutations in Conradi-Hünermann-Happle syndrome." in: European journal of dermatology : EJD, Vol. 18, Issue 4, pp. 391-3, (2008) (PubMed).

Lu, Dollé, Imholz, van t Slot, Verschuren, Wijmenga, Feskens, Boer: "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations." in: Journal of lipid research, Vol. 49, Issue 12, pp. 2582-9, (2008) (PubMed).

Steijlen, van Geel, Vreeburg, Marcus-Soekarman, Spaapen, Castelijns, Willemsen, van Steensel: "Novel EBP gene mutations in Conradi-Hünermann-Happle syndrome." in: The British journal of dermatology, Vol. 157, Issue 6, pp. 1225-9, (2007) (PubMed).

Details zu EBP

Target: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Andere Bezeichnung: EBP

Hintergrund: The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).

Molekulargewicht: 26353

NCBI Accession: NP_006570

UniProt: Q15125