DHODH Antikörper (AA 166-194)

Produktnummer ABIN1881259

Produktdetails anti-DHODH Antikörper

Target: DHODH (Dihydroorotate Dehydrogenase (DHODH))

Bindungsspezifität: AA 166-194

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DHODH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DHODH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of human DHODH.

Klon: RB40540

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-DHODH Antikörper (ABIN1881259)

Hail, Chen, Kepa, Bushman, Shearn: "Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis." in: Free radical biology & medicine, Vol. 49, Issue 1, pp. 109-16, (2010) (PubMed).

Ng, Buckingham, Lee, Bigham, Tabor, Dent, Huff, Shannon, Jabs, Nickerson, Shendure, Bamshad: "Exome sequencing identifies the cause of a mendelian disorder." in: Nature genetics, Vol. 42, Issue 1, pp. 30-5, (2009) (PubMed).

Grabar, Rozman, Logar, Praprotnik, Dolzan: "Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 68, Issue 8, pp. 1367-8, (2009) (PubMed).

Pawlik, Herczynska, Kurzawski, Safranow, Dziedziejko, Drozdzik: "The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide." in: Pharmacogenomics, Vol. 10, Issue 2, pp. 303-9, (2009) (PubMed).

Details zu DHODH

Target: DHODH (Dihydroorotate Dehydrogenase (DHODH))

Andere Bezeichnung: DHODH (DHODH Produkte)

Synonyme: DHOdehase antikoerper, POADS antikoerper, URA1 antikoerper, 2810417D19Rik antikoerper, AI834883 antikoerper, DDBDRAFT_0167009 antikoerper, DDBDRAFT_0185217 antikoerper, DDB_0167009 antikoerper, DDB_0185217 antikoerper, DHOD antikoerper, DHODase antikoerper, XFHB_12025 antikoerper, dhodh antikoerper, dihydroorotate dehydrogenase (quinone) antikoerper, dihydroorotate dehydrogenase antikoerper, dihydroorotate dehydrogenase (quinone) L homeolog antikoerper, DHODH antikoerper, Dhodh antikoerper, pyrD antikoerper, pyr4 antikoerper, Mrub_0263 antikoerper, Arnit_2124 antikoerper, Trad_2703 antikoerper, Ftrac_1484 antikoerper, Ndas_0799 antikoerper, Mesil_1876 antikoerper, Slip_0841 antikoerper, Spirs_1436 antikoerper, XFHB_RS12780 antikoerper, dhodh.L antikoerper

Hintergrund: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.

Molekulargewicht: 42867

NCBI Accession: NP_001352

UniProt: Q02127

Pathways: Ribonucleoside Biosynthetic Process, Protein targeting to Nucleus