CASR Antikörper (AA 260-287)

Produktnummer ABIN1881139

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CASR in WB. Er zeigt eine Reaktivität gegenüber Maus und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für CASR Antikörper (AA 260-287) (ABIN1881139)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41198

Produktdetails anti-CASR Antikörper

Bindungsspezifität: AA 260-287

Homologie: B, Pig, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CASR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-287 amino acids from the Central region of human CASR.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CASR Antikörper (ABIN1881139)

OSeaghdha, Yang, Glazer, Leak, Dehghan, Smith, Kao, Lohman, Hwang, Johnson, Hofman, Uitterlinden, Chen, Brown, Siscovick, Harris, Psaty, Coresh, Gudnason, Witteman, Liu, Kestenbaum, Fox, Köttgen: "Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels." in: Human molecular genetics, Vol. 19, Issue 21, pp. 4296-303, (2010) (PubMed).

Giroux, Elfassihi, Clément, Bussières, Bureau, Cole, Rousseau: "High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density." in: Bone, Vol. 47, Issue 5, pp. 975-81, (2010) (PubMed).

Details zu CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Andere Bezeichnung: CASR

Hintergrund: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq].

Molekulargewicht: 120675

NCBI Accession: NP_000379, NP_001171536

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis