CASQ2 Antikörper (AA 79-107)

Produktnummer ABIN1881138

Dieses Anti-CASQ2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CASQ2 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für CASQ2 Antikörper (AA 79-107) (ABIN1881138)

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASQ2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41817

Produktdetails anti-CASQ2 Antikörper

Bindungsspezifität: AA 79-107

Homologie: Rb

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CASQ2 Antikörper (ABIN1881138)

Kirchhefer, Wehrmeister, Postma, Pohlentz, Mormann, Kucerova, Müller, Schmitz, Schulze-Bahr, Wilde, Neumann: "The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling." in: Journal of molecular and cellular cardiology, Vol. 49, Issue 1, pp. 95-105, (2010) (PubMed).

Wei, Hanna, Beard, Dulhunty: "Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle." in: Cell calcium, Vol. 45, Issue 5, pp. 474-84, (2009) (PubMed).

Details zu CASQ2

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Andere Bezeichnung: CASQ2

Hintergrund: The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq].

Molekulargewicht: 46436

NCBI Accession: NP_001223

UniProt: O14958

Pathways: Negative Regulation of Transporter Activity