BRMS1 Antikörper (N-Term)

Produktnummer ABIN1881120

Dieses Anti-BRMS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BRMS1 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für BRMS1 Antikörper (N-Term) (ABIN1881120)

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRMS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40250

Produktdetails anti-BRMS1 Antikörper

Bindungsspezifität: AA 48-77, N-Term

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BRMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the N-terminal region of human BRMS1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-BRMS1 Antikörper (ABIN1881120)

Wu, McEwen, Harihar, Baker, DeWald, Zhou: "BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman microspectroscopy study." in: Cancer letters, Vol. 293, Issue 1, pp. 82-91, (2010) (PubMed).

Vaidya, Sanchez, Kim, Welch: "Expression of the Breast Cancer Metastasis Suppressor 1 (BRMS1) maintains in vitro chemosensitivity of breast cancer cells." in: Cancer letters, Vol. 281, Issue 1, pp. 100-7, (2009) (PubMed).

Frolova, Edmonds, Bodenstine, Seitz, Johnson, Feng, Welch, Frost: "A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers." in: Tumour biology, Vol. 30, Issue 3, pp. 148-59, (2009) (PubMed).

Cicek, Fukuyama, Cicek, Sizemore, Welch, Sizemore, Casey: "BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-kappaB binding site of the uPA promoter." in: Clinical & experimental metastasis, Vol. 26, Issue 3, pp. 229-37, (2009) (PubMed).

Details zu BRMS1

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Andere Bezeichnung: BRMS1

Hintergrund: This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Molekulargewicht: 28461

NCBI Accession: NP_056214

UniProt: Q9HCU9