BCL9L Antikörper (N-Term)
Kurzübersicht für BCL9L Antikörper (N-Term) (ABIN1881110)
Target
Alle BCL9L Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 147-176, N-Term
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Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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Immunogen
- This BCL9L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human BCL9L.
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Isotyp
- Ig Fraction
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Applikationshinweise
- WB: 1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Haltbarkeit
- 6 months
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: "Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor." in: Journal of molecular biology, Vol. 401, Issue 5, pp. 969-84, (2010) (PubMed).
: "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential." in: Gastroenterology, Vol. 137, Issue 1, pp. 165-75, (2009) (PubMed).
: "Crystal structure of a beta-catenin/BCL9/Tcf4 complex." in: Molecular cell, Vol. 24, Issue 2, pp. 293-300, (2006) (PubMed).
: "Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions." in: Genes & development, Vol. 18, Issue 18, pp. 2225-30, (2004) (PubMed).
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- BCL9L (B-Cell CLL/lymphoma 9-Like (BCL9L))
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Andere Bezeichnung
- BCL9L
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Hintergrund
- Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
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Molekulargewicht
- 157129
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NCBI Accession
- NP_872363
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UniProt
- Q86UU0
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Pathways
- Stem Cell Maintenance
Target
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