ASCL1 Antikörper (N-Term)

Produktnummer ABIN1881074

Der Kaninchen Polyklonal Anti-ASCL1-Antikörper wurde für WB validiert. Er ist geeignet, ASCL1 in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für ASCL1 Antikörper (N-Term) (ABIN1881074)

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASCL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41522

Produktdetails anti-ASCL1 Antikörper

Bindungsspezifität: AA 63-90, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ASCL1 Antikörper (ABIN1881074)

Phi, Kim, Eun, Wang, Park, Choi, Kim, Park, Cho, Kim: "Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas." in: Journal of neurosurgery. Pediatrics, Vol. 5, Issue 6, pp. 608-14, (2010) (PubMed).

McGaughey, McCallion: "Efficient discovery of ASCL1 regulatory sequences through transgene pooling." in: Genomics, Vol. 95, Issue 6, pp. 363-9, (2010) (PubMed).

Li, Zhong, Li, Huang, Wang, Zheng, Zhang: "[Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]." in: Zhongguo fei ai za zhi = Chinese journal of lung cancer, Vol. 13, Issue 4, pp. 317-21, (2010) (PubMed).

Deng, Yang, Le, Deng, Xu, Xiong, Zhu, Xie, Song, Jankovic: "Examination of the MASH1 gene in patients with Parkinson's disease." in: Biochemical and biophysical research communications, Vol. 392, Issue 4, pp. 548-50, (2010) (PubMed).

Improgo, Schlichting, Cortes, Zhao-Shea, Tapper, Gardner: "ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus." in: Molecular cancer research : MCR, Vol. 8, Issue 2, pp. 194-203, (2010) (PubMed).

Details zu ASCL1

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Andere Bezeichnung: ASCL1

Hintergrund: This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Molekulargewicht: 25454

NCBI Accession: NP_004307

UniProt: P50553

Pathways: Dopaminergic Neurogenesis