AKTIP Antikörper (C-Term)

Produktnummer ABIN1881052

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AKTIP in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für AKTIP Antikörper (C-Term) (ABIN1881052)

Target: AKTIP (AKT Interacting Protein (AKTIP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKTIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB38675

Produktdetails anti-AKTIP Antikörper

Bindungsspezifität: AA 262-288, C-Term

Homologie: C, Pr, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-AKTIP Antikörper (ABIN1881052)

Quaye, Dafou, Ramus, Song, Gentry-Maharaj, Maharaj, Notaridou, Hogdall, Kjaer, Christensen, Hogdall, Easton, Jacobs, Menon, Pharoah, Gayther: "Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival." in: Human molecular genetics, Vol. 18, Issue 10, pp. 1869-78, (2009) (PubMed).

Xu, Sowa, Chen, Li, Gygi, Harper: "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5059-71, (2008) (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, (2007) (PubMed).

Details zu AKTIP

Target: AKTIP (AKT Interacting Protein (AKTIP))

Andere Bezeichnung: AKTIP

Hintergrund: The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Molekulargewicht: 33128

NCBI Accession: NP_001012398, NP_071921

UniProt: Q9H8T0