S1PR5 Antikörper (C-Term)

Produktnummer ABIN187790

Der Kaninchen Polyklonal anti-S1PR5 Antikörper wird verwendet zum Nachweis von S1PR5 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für S1PR5 Antikörper (C-Term) (ABIN187790)

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-S1PR5 Antikörper

Bindungsspezifität: C-Term

Spezifität: Reacts with EDG-8. Species Reactivity: Human, other species not tested.

Sterilität: Sterile filtered

Immunogen: Synthetic peptide derived from the C-terminus of the human EDG-8 protein.

Anwendungsinformationen

Applikationshinweise: Western Blot: Use at 5-10 µg/mL using a human EDG-8 receptor transfected cell line. Detects recombinant EDG-8 receptors with a band of about 42 kDa. [ Note: Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for Western blot development.] The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified sterile filtered polyclonal antibody against human EDG-8 (CT). 100 µg/100 µL in PBS with 0.08% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu S1PR5

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Andere Bezeichnung: EDG-8 / S1P5

Hintergrund: Endothelial Cell Differentiation Gene-8 (EDG-8) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-8 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-8 is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.