S1PR4 Antikörper (C-Term)

Produktnummer ABIN187788

Der Kaninchen Polyklonal anti-S1PR4 Antikörper (ABIN187788) detektiert spezifisch S1PR4 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für S1PR4 Antikörper (C-Term) (ABIN187788)

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-S1PR4 Antikörper

Bindungsspezifität: C-Term

Spezifität: Reacts with EDG-6. Species Reactivity: Human, other species not tested. Positive Control: RH7777 cells transfected with EDG-6 protein. The optimal dilution for a specific application should be determined by the researcher.

Sterilität: 0.2 μm filtered

Immunogen: Synthetic peptide derived from the C-terminal of the EDG-6 receptor.

Anwendungsinformationen

Applikationshinweise: Western Blot: Use at 5-10 µg/ml using a human EDG-6 receptor transfected cell line. Detects a band of approximately 45 kDa in Cos cells transfected with full length human EDG-6. Due to low expression of EDG receptors, we recommend using Pierce Femto Signal substrate for western blot development.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 100 µg purified antibody at 1 mg/ml in PBS with 0.08% sodium azide. Solution was sterile filtered at 0.2 µm.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu S1PR4

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Andere Bezeichnung: EDG-6 / S1P4

Hintergrund: EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).