JUP Antikörper

Produktnummer ABIN187369

Dieser Maus Monoklonal Antikörper detektiert spezifisch JUP in WB, IF und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für JUP Antikörper (ABIN187369)

Target: JUP (Junction Plakoglobin (JUP))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser JUP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 15F11

Produktdetails anti-JUP Antikörper

Spezifität: Reacts with human plakoglobin. Cross-reacts with rat and weakly cross-reacts with mouse plakoglobin. Species Reactivity: Human, mouse and rat. Others not tested.

Sterilität: 0.2 μm filtered

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunofluorescence: (cells fixed in paraformaldehyde) Use at a 1:10 dilution Immunoprecipitation Western blot: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer.

Lagerung: 4 °C

Details zu JUP

Target: JUP (Junction Plakoglobin (JUP))

Andere Bezeichnung: Junction plakoglobin

Hintergrund: Plakoglobin belongs together with alpha- and beta-catenin to the catenin family. Catenins mediate cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoblobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas.

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location