Der Maus Monoklonal anti-Desmoglein 3 Antikörper wird verwendet zum Nachweis von Desmoglein 3 in Proben von Human. Er wurde validiert für WB, IF, IP und IHC (p).
Reacts with the 140 kDa desmoglein 3 protein. Does not cross-react with desmoglein 1 or desmoglein 2. The antibody does not inhibit biological activity of desmoglein 3. Species Reactivity: Human. Others not tested.
DSG3
Reaktivität: Human
WB, IF
Wirt: Kaninchen
Monoclonal
unconjugated
Applikationshinweise
Immunofluorescence: Use at a 1:10 dilution Immunohistochemistry (paraffin embedded sections) Immunoprecipitation Western blot: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer and 0.02% sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Target
Desmoglein 3 (DSG3)
Andere Bezeichnung
Desmoglein-3
Hintergrund
Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments.