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Factor VIII Antikörper

F8 Reaktivität: Human, Schwein WB, ELISA, RIA Wirt: Maus Monoclonal RFF-VIIIC-8 unconjugated
Produktnummer ABIN1820031
  • Target Alle Factor VIII (F8) Antikörper anzeigen
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Reaktivität
    • 90
    • 58
    • 30
    • 17
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Schwein
    Wirt
    • 88
    • 17
    • 3
    • 1
    Maus
    Klonalität
    • 94
    • 15
    Monoklonal
    Konjugat
    • 44
    • 15
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser Factor VIII Antikörper ist unkonjugiert
    Applikation
    • 50
    • 39
    • 39
    • 37
    • 23
    • 11
    • 10
    • 10
    • 10
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Radioimmunoassay (RIA)
    Spezifität
    Recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Clone RFF-VIIIC/8 is a very potent coagulation inhibitor. It recognizes an epitope towards the N-terminus of full-length Factor VIII. It also recognizes the 210kD, 90kD and 40kD cleavage products. This clone does not cross-react with von Willebrand factor.
    Keine Kreuzreaktivität
    Maus, Hund, Ratte (Rattus)
    Aufreinigung
    Protein G purified
    Immunogen
    Affinity purified human Factor VIII.

    Type of Immunogen: Purified protein
    Klon
    RFF-VIIIC-8
    Isotyp
    IgG1
    Top Product
    Discover our top product F8 Primärantikörper
  • Applikationshinweise
    Approved: ELISA (1:500 - 1:15000), RIA, WB
    Kommentare

    Target Species of Antibody: Human

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    PBS, 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    4°C or -20°C, Avoid freeze-thaw cycles.
  • Target
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Andere Bezeichnung
    F8 / FVIII / Factor VIII (F8 Produkte)
    Synonyme
    fb61d02 antikoerper, wu:fb61d02 antikoerper, Cf-8 antikoerper, Cf8 antikoerper, FVIII antikoerper, AHF antikoerper, DXS1253E antikoerper, F8B antikoerper, F8C antikoerper, HEMA antikoerper, coagulation factor VIIi antikoerper, coagulation factor VIII antikoerper, coagulation factor VIII, procoagulant component antikoerper, f7i antikoerper, F8 antikoerper
    Hintergrund
    Name/Gene ID: F8

    Synonyms: F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C
    Gen-ID
    2157
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