Factor VIII Antikörper

Produktnummer ABIN1820031

Dieses Anti-Factor VIII-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Factor VIII in WB, ELISA und RIA. Geeignet für Human und Schwein.

Kurzübersicht für Factor VIII Antikörper (ABIN1820031)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reaktivität: Human, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Factor VIII Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Radioimmunoassay (RIA)

Klon: RFF-VIIIC-8

Produktdetails anti-Factor VIII Antikörper

Spezifität: Recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Clone RFF-VIIIC/8 is a very potent coagulation inhibitor. It recognizes an epitope towards the N-terminus of full-length Factor VIII. It also recognizes the 210kD, 90kD and 40kD cleavage products. This clone does not cross-react with von Willebrand factor.

Keine Kreuzreaktivität: Maus, Hund, Ratte (Rattus)

Aufreinigung: Protein G purified

Immunogen: Affinity purified human Factor VIII.

Type of Immunogen: Purified protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (1:500 - 1:15000), RIA, WB

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Andere Bezeichnung: F8 / FVIII / Factor VIII

Hintergrund: Name/Gene ID: F8

Synonyms: F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C

Gen-ID: 2157