IL23R Antikörper (AA 59-87)

Produktnummer ABIN1819424

Der Ziege Polyklonal Anti-IL23R-Antikörper wurde für WB, IHC und IHC (p) validiert. Er ist geeignet, IL23R in Proben von Human und Maus zu detektieren.

Kurzübersicht für IL23R Antikörper (AA 59-87) (ABIN1819424)

Target: IL23R (Interleukin 23 Receptor (IL23R))

Reaktivität: Human, Maus

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IL23R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IL23R Antikörper

Bindungsspezifität: AA 59-87

Spezifität: Recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kD single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two domains. Multiple potential isoforms formed by alternative splicing are described. Recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4, the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis. Is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.

Aufreinigung: Affinity purified

Immunogen: Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%), Marmoset, Dog (97%), Gibbon, Monkey, Panda (93%), Ferret, Bovine, Cat, Horse, Pig (90%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-P (1:125), WB (1:500)

Usage: Use in IHC requires heat treatment prior to staining.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.1 % sodium azide, 0.1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu IL23R

Target: IL23R (Interleukin 23 Receptor (IL23R))

Andere Bezeichnung: IL23R

Hintergrund: Name/Gene ID: IL23R
Family: Interleukin

Synonyms: IL23R, IL-23 receptor, Interleukin 23 receptor, IBD17, IL-23R, Interleukin-23 receptor

Gen-ID: 149233

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation