CD300a Antikörper (PE)

Produktnummer ABIN1819155

Produktdetails anti-CD300a Antikörper (PE)

Target: CD300a (CD300A)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD300a Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.

Aufreinigung: Protein G purified

Immunogen: Polyclonal population of NK cells.

Type of Immunogen: Cells

Klon: P192

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Approved: Flo

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Reconstitute with 1 mL distilled water.

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA, 5 % sucrose

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze. Protect from light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C. Do not freeze. Protect from light.

Details zu CD300a

Target: CD300a (CD300A)

Andere Bezeichnung: CD300A (CD300A Produkte)

Hintergrund: Name/Gene ID: CD300A

Synonyms: CD300A, CD300a antigen, CD300a molecule, CMRF35-like molecule 8, CMRF35-H, CMRF35-H9, CLM-8, CMRF35H9, IGSF12, Inhibitory receptor protein 60, IRC2, IRC1, NK inhibitory receptor, CMRF-35-H9, CMRF-35H, CMRF35H, IRC1a, IRp60, Leukocyte membrane antigen

Gen-ID: 11314

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process