CD19 Antikörper (APC)

Produktnummer ABIN181826

Der Maus Monoklonal Anti-CD19 Antikörper wurde für FACS validiert. Er ist geeignet, CD19 in Proben von Human zu detektieren.

Kurzübersicht für CD19 Antikörper (APC) (ABIN181826)

Target: CD19 (CD19 Molecule (CD19))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD19 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: LT19

Produktdetails anti-CD19 Antikörper (APC)

Spezifität: This antibody recognizes the CD19 cell surface antigen. It labels all B lymphocytes in peripheral blood and spleen but is negative on granulocytes, monocytes, platelets, T lymphocytes and erythrocytes. This antibody is useful for enumerating normal B lymphocytes and typing B cell malignancies by Flow cytometry and Immunofluorescence. The antibody reacts with most B cell malignancies including chronic leukaemia and most lymphomas, but not multiple myeloma.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1 mL distilled water.

Buffer: PBS, pH 7.4, containing 1 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to and following reconstitution store the antibody at 2-8 °C for one month. Prior to reconstitution store at -20 °C for one year or following reconstitution at -20 °C for 6 month.

Haltbarkeit: 12 months

Details zu CD19

Target: CD19 (CD19 Molecule (CD19))

Andere Bezeichnung: CD19

Hintergrund: CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 Molecule is expressed on 100 % of the peripheral B cells as defined by expression of kappa or lamda light chains. It is expressed on approximately 10 % of normal human peripheral blood cells and approximately 60 % of splenic lymphocytes. It is not expressed on granulocytes, monocytes or T cells as defined by CD3 expression. CD19 defines a pan B antigen which is expressed from the earliest stages of B progenitor development, but is lost on terminal differentiation to plasma cells. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. The CD19 antigen is expressed on approximately 12 % of peripheral blood lymphocytes. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12

Gen-ID: 930

NCBI Accession: NP_001171569

UniProt: P15391

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung