Botulinum Neurotoxin Type B (BoNT/B) Antikörper

Produktnummer ABIN179725

Produktdetails

Target: Botulinum Neurotoxin Type B (BoNT/B)

Reaktivität: Clostridium botulinum

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Cell-ELISA (cELISA), Flow Cytometry (FACS)

Spezifität: Anti-BoNT/B

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding BoNT/B

Klon: GR-3G7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 2 mg/mL

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Antigendetails

Target: Botulinum Neurotoxin Type B (BoNT/B)

Andere Bezeichnung: BoNT B, Lightchain (BoNT/B Produkte)

Substanzklasse: Bacteria

Hintergrund: Botulinum neurotoxin type B (BoNT/B) is produced by Clostridium botulinum, a genetically diverse class of anaerobic, spore-forming, gram-positive bacilli. Seven different botulinum toxin groups have been identified serologically and are called botulinum toxin type A,B,C,D,E,F, and G. BoNT/B is a two-chain polypeptide with a 100-kDa heavy chain, which is responsible for neurospecific binding joined by a disulphide bond to a 50-kDa light chain, a zinc-endopeptidase which blocks neurotransmitter release. BoNT/B is one of the most poisonous naturally occurring substances. It inhibits acetylcholine release from neuromuscular junctions while it is used as an important therapeutic mainstay in the treatment of spasticity disorders and as a cosmetic treatment.