CCR4 Antikörper
Kurzübersicht für CCR4 Antikörper (ABIN179723)
Target
Alle CCR4 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Spezifität
- Anti-human CCR4
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Aufreinigung
- Protein G
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Immunogen
- immunisation with human CCR4 peptide
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Isotyp
- IgG2a
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Applikationshinweise
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Flow cytometry: 1.2 µg/10^6 cells
Immunofluorescence: 1 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. -
Kommentare
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Synonyms: CC chemokine receptor 4
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 2 mg/mL
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Buffer
- PBS, pH 7.2
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- short term: 2 °C - 8 °C, long term: -20 °C
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- CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))
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Andere Bezeichnung
- CCR4
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Hintergrund
- CCR4 (CC chemokine receptor 4) molecule belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane bound molecules composed of 7-transmembrane domains and coupled to G-proteins. CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells. It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways.
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UniProt
- P51679
Target
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