Abeta 38/40/42 (AA 1-16) Antikörper

Produktnummer ABIN1742437

Dieser Maus Monoklonal Antikörper detektiert spezifisch Abeta 38/40/42 in IHC, IHC (p), ELISA und WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für Abeta 38/40/42 (AA 1-16) Antikörper (ABIN1742437)

Target: Abeta 38/40/42

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)

Klon: NT78

Produktdetails

Bindungsspezifität: AA 1-16

Verwendungszweck: Mouse anti-Abeta38/40/42/43 IgG

Spezifität: Specific for Abeta 38, 40, 42.

Kreuzreaktivität (Details): Reacts with: human (P05067), mouse (P12023). Other species not tested yet.

Aufreinigung: purified IgG

Immunogen: Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067) Epitop AA 4 to 16 from human Abeta (UniProt Id: P05067)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB:1 : 500 up to 1 : 1000 ,

Kommentare:

ELISA: Suitable as capture antibody for sandwich-ELISA as detector antibody (protocol for sandwich-ELISA).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 100 μLH2O to get a 1 mg/mL solution in PBS.

Buffer: PBS. Azide was added before lyophilization.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Lagerung: -20 °C,-80 °C,4 °C

Informationen zur Lagerung: Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Do not freeze!

Referenzen

Jawhar, Wirths, Schilling, Graubner, Demuth, Bayer et al.: "Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in ..." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4454-60, (2011) (PubMed).

Wirths, Erck, Martens, Harmeier, Geumann, Jawhar, Kumar, Multhaup, Walter, Ingelsson, Degerman-Gunnarsson, Kalimo, Huitinga, Lannfelt, Bayer: "Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis." in: The Journal of biological chemistry, Vol. 285, Issue 53, pp. 41517-24, (2010) (PubMed).

Antigendetails

Target: Abeta 38/40/42

Hintergrund:

Synonyms: Beta-APP, ABPP, Abeta, Abeta 38, Abeta 40, Abeta 42, Abeta 43

Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

UniProt: P05067