Abeta-pE3 (AA 3-7) Antikörper

Produktnummer ABIN1742433

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-Abeta-pE3 Antikörper (Klon 1-57) (ABIN1742433) detektiert spezifisch Abeta-pE3 in IHC (p) und WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Abeta-pE3 (AA 3-7) Antikörper (ABIN1742433)

Target: Abeta-pE3

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Klon: 1-57

Produktdetails

Bindungsspezifität: AA 3-7

Verwendungszweck: Mouse anti-Abeta-pE3 IgG

Spezifität: Specific for Abeta-pE3.

Kreuzreaktivität (Details): Reacts with: human (P05067), rat (P08592), mouse (P12023). Other species not tested yet.

Aufreinigung: purified IgG

Immunogen: Synthetic peptide corresponding to AA 3 to 7 from human Abeta-pE3 (UniProt Id: P05067) Epitop AA 3 to 5 from human Abeta-pE3 (UniProt Id: P05067)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB:1 : 1000 ICC:not tested yet IHC:not tested yet IHC-P:1 : 1000 up to 1 : 5000,

Kommentare:

WB: Detects purified Abeta pE3. Complex samples like brain extracts still have to be tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 100 μLH2O to get a 1 mg/mL solution in PBS.

Buffer: PBS. Albumin and azide were added for stabilization.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Lagerung: -20 °C,-80 °C,4 °C

Informationen zur Lagerung: Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Albumin and azide were added for stabilization. Do not freeze!

Referenzen

Antonios, Saiepour, Bouter, Richard, Paetau, Verkkoniemi-Ahola, Lannfelt, Ingelsson, Kovacs, Pillot, Wirths, Bayer: "N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody." in: Acta neuropathologica communications, Vol. 1, Issue 1, pp. 56, (2013) (PubMed).

Wittnam, Portelius, Zetterberg, Gustavsson, Schilling, Koch, Demuth, Blennow, Wirths, Bayer: "Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8154-62, (2012) (PubMed).

Antigendetails

Target: Abeta-pE3

Hintergrund:

Synonyms: pE3-Abeta, pyro-Glu-Abeta, pGlu-Abeta, Abeta(3(pE)-40/42), pyro-Abeta

Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

UniProt: P05067