SHANK3 Antikörper (C-Term)

Produktnummer ABIN1742347

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SHANK3 in WB, ICC und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Ratte und Maus. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für SHANK3 Antikörper (C-Term) (ABIN1742347)

Target: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHANK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Güteklasse: KO Validated

Produktdetails anti-SHANK3 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-Shank3 antiserum

Spezifität: Specific for shank 3.

Kreuzreaktivität (Details): Reacts with: rat (Q9JLU4), mouse (Q4ACU6). Other species not tested yet.

Aufreinigung: antiserum

Immunogen: Recombinant protein corresponding to residues near the carboxy terminus of rat Shank3 (UniProt Id: Q9JLU4)

Anwendungsinformationen

Applikationshinweise: WB:1 : 1000

Kommentare:

IHC: For best results the antibody requires a mild fixation protocol (2 % PFA in sodium acetate buffer, pH 6).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 200 μLH2O, then aliquot and store at -20 °C until use.

Handhabung: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Antibodies should be stored at +4°C when still lyophilized. Do not freeze!

Referenzen für anti-SHANK3 Antikörper (ABIN1742347)

Tao-Cheng, Toy, Winters, Reese, Dosemeci: "Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses." in: PLoS ONE, Vol. 11, Issue 5, pp. e0153979, (2016) (PubMed).

Wei, Ma, Ding, Jin, Liu, Chang, Hu, Yu: "Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder." in: Neurochemical research, Vol. 41, Issue 11, pp. 3129-3137, (2016) (PubMed).

Wei, Ma, Liu, Ding, Jin, Wang, Hu, Yu: "Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism." in: Biochimica et biophysica acta, Vol. 1862, Issue 10, pp. 1918-25, (2016) (PubMed).

Hagmeyer, Mangus, Boeckers, Grabrucker: "Effects of trace metal profiles characteristic for autism on synapses in cultured neurons." in: Neural plasticity, Vol. 2015, pp. 985083, (2015) (PubMed).

Details zu SHANK3

Target: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Andere Bezeichnung: Shank3

Hintergrund:

Synonyms: SPANK 3, Shanlk-3

Antigen Information: K.O. Shanks are multidomain proteins of the postsynaptic density

UniProt: Q9JLU4

Pathways: Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity