Alpha, beta Synuclein (AA 2-25) Antikörper

Produktnummer ABIN1742282

Es sind 7+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-Alpha, beta Synuclein Antikörper wird verwendet zum Nachweis von Alpha, beta Synuclein in Proben von Human, Maus, Ratte und Zebrafisch (Danio rerio). Er wurde validiert für WB, ICC, IHC, IHC (p) und IP.

Kurzübersicht für Alpha, beta Synuclein (AA 2-25) Antikörper (ABIN1742282)

Target: Alpha, beta Synuclein

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Produktdetails

Bindungsspezifität: AA 2-25

Verwendungszweck: Rabbit anti-alpha/beta Synuclein antiserum

Spezifität: Recognizes alpha synuclein and beta synuclein.

Kreuzreaktivität (Details): Reacts with: rat (P37377, Q63754), mouse (O55042, Q91ZZ3), zebrafish, human (P37840, Q16143). Other species not tested yet.

Aufreinigung: antiserum

Immunogen: Synthetic peptide corresponding to AA 2 to 25 from human alpha-Synuclein (UniProt Id: P37840)

Anwendungsinformationen

Applikationshinweise: WB:1 : 1000 , IP:yes ICC:1 : 500, IHC:1 : 500, IHC-P:1 : 1000 up to 1 : 2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 200 μLH2O, then aliquot and store at -20 °C until use.

Handhabung: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Antibodies should be stored at +4°C when still lyophilized. Do not freeze!

Referenzen

Wilhelm, Mandad, Truckenbrodt, Kröhnert, Schäfer, Rammner, Koo, Claßen, Krauss, Haucke, Urlaub, Rizzoli: "Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins." in: Science (New York, N.Y.), Vol. 344, Issue 6187, pp. 1023-8, (2014) (PubMed).

Siebert, Kahle, Kramer, Isik, Schlüter, Schulz-Schaeffer, Brück: "Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain." in: Journal of neurochemistry, Vol. 114, Issue 4, pp. 1007-18, (2010) (PubMed).

Tong, Wong, Guttman, Ang, Forno, Shimadzu, Rajput, Muenter, Kish, Hornykiewicz, Furukawa: "Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation." in: Brain : a journal of neurology, Vol. 133, Issue Pt 1, pp. 172-88, (2010) (PubMed).

Cole, Dieuliis, Leo, Mitchell, Nussbaum: "Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification." in: Experimental cell research, Vol. 314, Issue 10, pp. 2076-89, (2008) (PubMed).

Colapinto, Mila, Giraudo, Stefanazzi, Molteni, Rossetti, Bergamasco, Lopiano, Fasano: "alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity." in: Biochemical and biophysical research communications, Vol. 349, Issue 4, pp. 1294-300, (2006) (PubMed).

Takamori, Holt, Stenius, Lemke, Grønborg, Riedel, Urlaub, Schenck, Brügger, Ringler, Müller, Rammner, Gräter, Hub, De Groot, Mieskes, Moriyama, Klingauf, Grubmüller, Heuser, Wieland, Jahn: "Molecular anatomy of a trafficking organelle." in: Cell, Vol. 127, Issue 4, pp. 831-46, (2006) (PubMed).

Steinacker, Schwarz, Reim, Brechlin, Jahn, Kratzin, Aitken, Wiltfang, Aguzzi, Bahn, Baxter, Brose, Otto: "Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1339-46, (2005) (PubMed).

Antigendetails

Target: Alpha, beta Synuclein

Andere Bezeichnung: alpha/beta Synuclein

Hintergrund:

Synonyms: alpha/beta Synuclein, SNCA, SNCB, NACP, Synuclein

Antigen Information: Synucleins are involved in Parkinson's and Alzheimer's Disease

UniProt: P37840