Neuroligin 1 Antikörper (AA 718-843) (Atto 488)

Produktnummer ABIN1741307

Der Maus Monoklonal Anti-Neuroligin 1-Antikörper wurde für WB, IHC, ICC und IF validiert. Er ist geeignet, Neuroligin 1 in Proben von Ratte zu detektieren.

Kurzübersicht für Neuroligin 1 Antikörper (AA 718-843) (Atto 488) (ABIN1741307)

Target: Neuroligin 1 (NLGN1)

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Neuroligin 1 Antikörper ist konjugiert mit Atto 488

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: S97A-31

Produktdetails anti-Neuroligin 1 Antikörper (Atto 488)

Bindungsspezifität: AA 718-843

Spezifität: Detects ~120 kDa. Does not cross-react with other Neuroligins.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1. Mouse: 99% identity (125/126 amino acids identical). Human: 99% identity (125/126 amino acids identical) >40% identity with Neuroligin-2 and -3.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

2 μg/ml of ABIN1741307 was sufficient for detection of Neuroligin-1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu Neuroligin 1

Target: Neuroligin 1 (NLGN1)

Andere Bezeichnung: Neuroligin 1

Hintergrund: Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.

Gen-ID: 116647

UniProt: Q62765

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis