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NrCAM Antikörper (Extracellular Domain)

This anti-NrCAM antibody (ABIN1741287) is a Mouse Monoclonal antibody detecting NrCAM in WB, ICC, IF. Suitable for Mouse.
Produktnummer ABIN1741287

Quick Overview for NrCAM Antikörper (Extracellular Domain) (ABIN1741287)

Target

Alle NrCAM (NRCAM) Antikörper anzeigen
NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Reaktivität

  • 28
  • 25
  • 12
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 1
  • 1
Maus

Wirt

  • 26
  • 24
Maus

Klonalität

  • 26
  • 24
Monoklonal

Konjugat

  • 31
  • 5
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser NrCAM Antikörper ist unkonjugiert

Applikation

  • 43
  • 19
  • 19
  • 13
  • 12
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon

S364-51
  • Bindungsspezifität

    • 16
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 30-845, Extracellular Domain

    Spezifität

    Detects ~160 kDa.

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Protein G Purified

    Immunogen

    Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM. Rat: 96% identity (795/822 amino acids identical). Human: 91% identity (753/822 amino acids identical) ~50% identity with Neurofascin.

    Isotyp

    IgG2a
  • Applikationshinweise

    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.

    Kommentare

    1 μg/ml of ABIN1741287 was sufficient for detection of NrCAM in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C
  • Target

    NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

    Andere Bezeichnung

    NrCAM

    Hintergrund

    Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues. In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31.1-q31.2.

    Gen-ID

    319504

    NCBI Accession

    NP_001139503

    UniProt

    Q810U4

    Pathways

    Regulation of Cell Size
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