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WHSC2 Antikörper (AA 280-511)

WHSC2 Reaktivität: Human, Ratte WB, ELISA, IHC, FACS, ICC Wirt: Maus Monoclonal 6B11H8 unconjugated
Produktnummer ABIN1724802
  • Target Alle WHSC2 Antikörper anzeigen
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    Bindungsspezifität
    • 8
    • 7
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 280-511
    Reaktivität
    • 48
    • 16
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 33
    • 14
    • 1
    Maus
    Klonalität
    • 37
    • 11
    Monoklonal
    Konjugat
    • 24
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser WHSC2 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 20
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. coli.
    Klon
    6B11H8
    Isotyp
    IgG2b
    Top Product
    Discover our top product WHSC2 Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).

    Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." in: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).

  • Target
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    Andere Bezeichnung
    WHSC2 (WHSC2 Produkte)
    Synonyme
    BcDNA:SD07139 antikoerper, CG5874 antikoerper, Dmel\\CG5874 antikoerper, NELF antikoerper, NELF-A antikoerper, Whsc2 antikoerper, fi75f03 antikoerper, whsc2 antikoerper, wu:fi75f03 antikoerper, MGC85474 antikoerper, WHSC2 antikoerper, nelfa antikoerper, nelf-a antikoerper, p/okcl.15 antikoerper, Whsc2h antikoerper, Negative elongation factor A antikoerper, negative elongation factor complex member A antikoerper, negative elongation factor complex member A L homeolog antikoerper, negative elongation factor complex member A, Whsc2 antikoerper, Nelf-A antikoerper, Nelfa antikoerper, nelfa antikoerper, nelfa.L antikoerper, NELFA antikoerper
    Hintergrund

    Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. , ,

    Aliases: NELFA, NELF-A, P/OKcl.15

    Molekulargewicht
    57.3 kDa
    Gen-ID
    7469
    HGNC
    7469
    Pathways
    Chromatin Binding
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