ZBTB7B Antikörper
Kurzübersicht für ZBTB7B Antikörper (ABIN1724728)
Target
Alle ZBTB7B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- ZBTB7B Antibody
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Aufreinigung
- Ascitic fluid
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Immunogen
- Purified recombinant fragment of human ZBTB7B expressed in E. Coli.
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Isotyp
- IgG1
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Applikationshinweise
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ELISA: 1/10000
ICC: 1/200 - 1/1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Ascitic fluid containing 0.03 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Runx and ThPOK: a balancing act to regulate thymocyte lineage commitment." in: Journal of cellular biochemistry, Vol. 107, Issue 6, pp. 1037-45, (2009) (PubMed).
: "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration." in: The Journal of biological chemistry, Vol. 275, Issue 35, pp. 27421-38, (2000) (PubMed).
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: "Runx and ThPOK: a balancing act to regulate thymocyte lineage commitment." in: Journal of cellular biochemistry, Vol. 107, Issue 6, pp. 1037-45, (2009) (PubMed).
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- ZBTB7B (Zinc Finger and BTB Domain Containing 7B (ZBTB7B))
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Andere Bezeichnung
- ZBTB7B
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Hintergrund
- ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
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Molekulargewicht
- 58 kDa
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UniProt
- O15156
Target
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