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TNK1 Antikörper (AA 451-560)
TNK1
Reaktivität: Human
ELISA
Wirt: Maus
Monoclonal
1B5G3
unconjugated
Produktnummer ABIN1724711
Produktdetails anti-TNK1 Antikörper
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Target
Alle TNK1 Antikörper anzeigen
TNK1
(Tyrosine Kinase, Non-Receptor, 1 (TNK1))
Bindungsspezifität
Alle Epitope für TNK1 Antikörper
AA 451-560
Reaktivität
Alle Reaktivitäten für TNK1 Antikörper
Human
Wirt
Alle Wirte für TNK1 Antikörper
Maus
Klonalität
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Monoklonal
Konjugat
Alle Konjugate für TNK1 Antikörper
Dieser TNK1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TNK1 Antikörper
ELISA
Verwendungszweck
TNK1 Antibody
Aufreinigung
Ascitic fluid
Immunogen
Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
Klon
1B5G3
Isotyp
IgG1
Top Product
Discover our top product TNK1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
ELISA: 1/10000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Referenzen für anti-TNK1 Antikörper (ABIN1724711)
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Azoitei, Brey, Busch, Fulda, Adler, Seufferlein : "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. " in: Oncogene , Vol. 26 , Issue 45 , pp. 6536-45 , (2007 ) (PubMed ).
Hoare, Hoare, Smith, Kalmaz, Small, Stratford May : "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. " in: Oncogene , Vol. 22 , Issue 23 , pp. 3562-77 , (2003 ) (PubMed ).
Details zu TNK1
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Target
TNK1
(Tyrosine Kinase, Non-Receptor, 1 (TNK1))
Andere Bezeichnung
TNK1 (TNK1 Produkte )
Hintergrund
TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Gen-ID
8711
UniProt
Q13470
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