TNK1 Antikörper (AA 451-560)

Produktnummer ABIN1724711

Der Maus Monoklonal Anti-TNK1-Antikörper wurde für ELISA validiert. Er ist geeignet, TNK1 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für TNK1 Antikörper (AA 451-560) (ABIN1724711)

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNK1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 1B5G3

Produktdetails anti-TNK1 Antikörper

Bindungsspezifität: AA 451-560

Verwendungszweck: TNK1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-TNK1 Antikörper (ABIN1724711)

Azoitei, Brey, Busch, Fulda, Adler, Seufferlein: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, (2007) (PubMed).

Hoare, Hoare, Smith, Kalmaz, Small, Stratford May: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, (2003) (PubMed).

Details zu TNK1

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Andere Bezeichnung: TNK1

Hintergrund: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Gen-ID: 8711

UniProt: Q13470