KAT5 Antikörper

Produktnummer ABIN1724672

Der Maus Monoklonal Anti-KAT5-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, KAT5 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für KAT5 Antikörper (ABIN1724672)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KAT5 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Klon: 3F9

Produktdetails anti-KAT5 Antikörper

Verwendungszweck: TIP60 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human TIP60 expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-KAT5 Antikörper (ABIN1724672)

Raisner, Madhani: "Patterning chromatin: form and function for H2A.Z variant nucleosomes." in: Current opinion in genetics & development, Vol. 16, Issue 2, pp. 119-24, (2006) (PubMed).

Jin, Cai, Li, Conaway, Workman, Conaway, Kusch: "In and out: histone variant exchange in chromatin." in: Trends in biochemical sciences, Vol. 30, Issue 12, pp. 680-7, (2005) (PubMed).

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: TIP60

Hintergrund: HTATIP (HIV-1 Tat interacting protein TIP60, about 60 kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Molekulargewicht: 60 kDa

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway