LGR4 Antikörper

Produktnummer ABIN1720913

Der Ratte-Monoklonal Anti-LGR4-Antikörper wurde für FACS und cELISA validiert. Er ist geeignet zum Nachweis von LGR4 in Proben aus Human. }

Kurzübersicht für LGR4 Antikörper (ABIN1720913)

Target: LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser LGR4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Klon: BBX-1H1

Produktdetails anti-LGR4 Antikörper

Spezifität: Anti-human LGR4

Keine Kreuzreaktivität: Maus

Produktmerkmale: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding human LGR4

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Kommentare:

Synonyms: GPR48

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Details zu LGR4

Target: LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))

Andere Bezeichnung: LGR4

Hintergrund: LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4, GPR48) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains. LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart. LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.

UniProt: Q9BXB1