CMKLR1 Antikörper (AA 151-250)

Produktnummer ABIN1715118

Dieses Anti-CMKLR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CMKLR1 in WB, ELISA, IF (cc), IF (p), FACS, IHC (p), ICC und IHC (fro). Geeignet für Human, Maus, Ratte und Schwein. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für CMKLR1 Antikörper (AA 151-250) (ABIN1715118)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CMKLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CMKLR1 Antikörper

Bindungsspezifität: AA 151-250

Kreuzreaktivität: Human, Maus, Schwein, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CMKLR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CMKLR1 Antikörper (ABIN1715118)

Qu, Zhang, Yao, Song, Nikolic-Paterson, Li: "Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation." in: The Journal of pathology, Vol. 228, Issue 4, pp. 506-19, (2014) (PubMed).

Peng, Yu, Liu, Li, He, Cheng, Ye: "The Chemerin Receptor CMKLR1 is a Functional Receptor for Amyloid-? Peptide." in: Journal of Alzheimer's disease : JAD, (2014) (PubMed).

Details zu CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Andere Bezeichnung: CMKLR1

Hintergrund:

Synonyms: DEZ, Gpcr27, ChemR23, mcmklr1, Chemokine-like receptor 1, G-protein coupled receptor DEZ, Cmklr1

Background: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism.

Gen-ID: 14747

UniProt: P97468