ZAK Antikörper (AA 1-100)

Produktnummer ABIN1714238

Der Kaninchen Polyklonal Anti-ZAK-Antikörper wurde für ELISA, IHC (p), IF (cc), IF (p), ICC und IHC (fro) validiert. Er ist geeignet, ZAK in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für ZAK Antikörper (AA 1-100) (ABIN1714238)

Target: ZAK (Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZAK Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ZAK Antikörper

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZAK/HCCS4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ZAK

Target: ZAK (Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))

Andere Bezeichnung: ZAK/HCCS4

Hintergrund:

Synonyms: AZK, Cervical cancer suppressor gene 4 protein, HCCS 4, HCCS-4, HCCS4, Human cervical cancer suppressor gene 4 protein, Leucine zipper and sterile alpha mot containing kinase, Leucine zipper- and sterile alpha mot-containing kinase, Mitogen activated protein kinase kinase kinase MLT, Mitogen-activated protein kinase kinase kinase MLT, Mixed lineage kinase 7, Mixed lineage kinase related kinase, Mixed lineage kinase related kinase MRK beta, Mixed lineage kinase with a leucine zipper and a sterile alpha mot, Mixed lineage kinase-related kinase, MLK 7, MLK like mitogen activated protein triple kinase, MLK related kinase, MLK-like mitogen-activated protein triple kinase, MLK-related kinase, MLK7, Mlklak, MLT, MLTK, MLTK_HUMAN, MRK, Sterile alpha mot and leucine zipper containing kinase AZK, Sterile alpha mot- and leucine zipper-containing kinase AZK, ZAK.

Background: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.

Gen-ID: 51776