GRB14 Antikörper (AA 221-320)

Produktnummer ABIN1713832

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GRB14 in ELISA, IF (cc), IF (p), IHC (p), ICC und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GRB14 Antikörper (AA 221-320) (ABIN1713832)

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB14 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GRB14 Antikörper

Bindungsspezifität: AA 221-320

Spezifität: This antibody may also detect the similar protein GRB10 due to an 83 % sequence similarity in the immunogen sequence.

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GRB 14

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu GRB14

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Andere Bezeichnung: GRB 14

Hintergrund:

Synonyms: Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14

Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Gen-ID: 2888

UniProt: Q14449