CXCR2 Antikörper (pSer347)

Produktnummer ABIN1713644

Der Kaninchen Polyklonal Anti-CXCR2-Antikörper wurde für WB, ELISA, ICC, IHC (p), IHC (fro), IF (p) und IF (cc) validiert. Er ist geeignet, CXCR2 in Proben von Maus zu detektieren.

Kurzübersicht für CXCR2 Antikörper (pSer347) (ABIN1713644)

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-CXCR2 Antikörper

Bindungsspezifität: pSer347

Kreuzreaktivität: Maus

Homologie: Human,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser347

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Andere Bezeichnung: CXCR2

Hintergrund:

Synonyms: CXCR2 phospho S347, CXCR2 phospho Ser347, p-CXCR2 phospho S347, p-CD182 phospho Ser347, CXC-chemokine receptor 2, CD 182, CD182, CD182 antigen, CDw128b, Chemokine CXC receptor 2, CMKAR2, CXCR 2, CXC R2, CXC-R2, CXCR2_HUMAN, C-X-C chemokine receptor type 2, CXCR-2, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B, IL-8 receptor type 2.

Background: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].

Gen-ID: 3579

Pathways: cAMP Metabolic Process