FUBP1, FUBP2 (AA 551-644) Antikörper (HRP)

Produktnummer ABIN1712266

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in WB, ELISA, IHC (fro) und IHC (p). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für FUBP1, FUBP2 (AA 551-644) Antikörper (HRP) (ABIN1712266)

Target: FUBP1, FUBP2

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: AA 551-644

Spezifität: This antibody detects both FUBP1 and FUBP2 (KHSRP)

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FUBP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: FUBP1, FUBP2

Andere Bezeichnung: FUBP1/2

Hintergrund:

Synonyms: Far upstream element-binding protein 1, FUBP1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V, Far upstream element-binding protein 2, KHSRP, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, FBP2, FUBP2

Background: FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Gen-ID: 8880

UniProt: Q96AE4