EYA4 Antikörper (AA 301-400) (HRP)

Produktnummer ABIN1712264

Der Kaninchen Polyklonal Anti-EYA4-Antikörper wurde für ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, EYA4 in Proben von Human zu detektieren.

Kurzübersicht für EYA4 Antikörper (AA 301-400) (HRP) (ABIN1712264)

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA4 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-EYA4 Antikörper (HRP)

Bindungsspezifität: AA 301-400

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EYA4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu EYA4

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Andere Bezeichnung: EYA4

Hintergrund:

Synonyms: CMD1J, Deafness, autosomal dominant 10, DFNA 10, DFNA10, dJ78N10.1 eyes absent Drosophila homolog 4, dJ78N10.1 eyes absent, EYA 4, eya4, EYA4_HUMAN, Eyes absent 4, Eyes absent homolog 4 Drosophila, Eyes absent homolog 4, HGNC:3522, OTTHUMP00000040267.

Background: A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).

Gen-ID: 2070

Pathways: Sensory Perception of Sound